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EDUCATIONAL QUALIFICATION :

  • 1991 -1995 MBBS Bangalore Medical College Bangalore University, Bangalore, India
  • 1998 - 2001 MD (Radiation Oncology) Kidwai Memorial Institute of Oncology Rajiv Gandhi University, Bangalore, India
  • 2004 PDCR (Professional Degree in Clinical Research)
  • 2004 - 2006 PGHM (Post Graduate Degree in Hospital Management, Indian Institute of Modern Management, Pune)


    • PROFESSIONAL EXPERIENCE :

  • 1997 (February – July) Resident, Curie Institute of Oncology St. Johns Medical College, Bangalore
  • 1997 (July – December) Resident, Department of Radiation Oncology KMIO, Bangalore
  • 2001 (May – November) Senior Resident, Department of Medical Oncology KMIO, Bangalore
  • 2001 November – 2002 June Senior Resident, Department of Radiation Oncology KMIO, Bangalore
  • 2002 June – 2003 April Adhoc – Lecturer, Department of Radiation Oncology KMIO, Bangalore
  • 2003 April – 2013 Assistant Professor, Department of Radiation Oncology KMIO, Bangalore
  • 2008 Visiting Consultant- Department of Radiation Oncology, Manipal Hospital.
  • 2009 Visiting Consultant- Department of Radiation Oncology, HCG (Health Cancer Global Group Hospitals)
  • 2013 - 2022 Associate Professor, Department of Radiation Oncology KMIO, Bangalore
  • 2022 – Present Professor, Department of Radiation Oncology KMIO,Bangalore


    AREA OF INTEREST :

  • Chemo-irradiation in Solid Malignancies
  • IMRT ( Intensity Modulated Radiotherapy )
  • IGRT ( Image Guided Radiotherapy )
  • Stereotactic Radiotherapy
  • Dose escalation/intensification and biological modeling of fractionation


    • ASSOCIATIONS :

  • Life Member, Association of Radiation Oncologists India.
  • Life Member, Indian Medical Association.
  • Life Member, Breast Cancer Foundation of India.
  • Life Member, Bangalore Oncology Group.


    • PUBLICATIONS :

    Contributing Author:
    Textbook: Clinical Approach to Oncology, Edd PP Bapsy
    Byward Viva Publisher Private Limited.


    CLINICAL RESEARCH EXPERIENCE :

    Co-Investigator :

    1. Prospective analysis of response and acute toxicity with concurrent chemoradiation with hydroxyurea in oral malignancy.(2000)
    2. Concurrent chemoradiation with docetaxel in oropharngeal Cancer.(2021)
    3. Role of Oral Pilocarpine in the Prophylaxis of Radiation Induced Xerostomia.(2010)
    4. A randomised study of the efficacy and safety of oncogene TN treatment as an adjunctive therapy to systemic chemotherapy and concurrent external beam radiation prior to localised or locoregional esophageal Cancer.(2008)
    5. Phase II 4 Arm study Of the role of hR-3( Humanised EGFR Antibody )in the Management of advanced Head and Neck cancer .hR-3/SCC-HN/IND Trial.(2004)
    6. Dosimetric evaluation of tumor cytoreduction during radiotherapy for esophageal carcinoma to identify optimal criteria for adaptation.(2018)
    7. Dose escalation in the treatment of locally advanced head and neck cancer with double SIB; A Feasibility study. (2019-ongoing trial)
    8. Study of simultaneous integrated boost vs standard fractionation in high grade glioma – a comparison of volumetric cytoreduction and dosimetric sparing. (2019)
    9. A study to evaluate the comparatively efficacy in volumetric cytoreduction and Feasibility in terms of toxicity of SMRT radiotherapy with DARS sparing versus IMRT SIB in the treatment of locally advanced head and neck cancer. (2018)


    Principal Investigator:

    10. Dose escalation to vertebral metastasis, using a hypo-fractionated simultaneous integrated boost technique [A pilot study]( 2021- ongoing .)
    11. A Pilot Study to Evaluate the potential benefits of staged Stereotactic Radiosurgery for the management of large brain metastasis in Oligometastatic disease.( 2021 – ongoing.)
    12.Evaluation of the potential role of probiotics for the treatment of Radiation induced mucositis in head and neck cancer patients. (2021 ongoing)


    International Journals:

    1. Bindhu Joseph,H Chiramana.Letter to editor Reference article: Extensive Subcutaneous Metastasis From Squamous Cell Carcinoma Of The Cervix In Patient With HIV. International Journal of Gynecological Cancer, Vol 14, pp.no. 176-177, 2004.
    2. Bindhu Joseph, Nimit Singhal Selective Cox-2 Inhibition: Do we finally have a cost-effective targeted therapy (Review Article). Austral – Asian Journal of Cancer, Vol 3, No.2, April 2004, pp. 159-162
    3. Nimit Singhal, Hemant dadhich, Bindhu Joseph.Changing Paradigms in the Management of Carcinoma Ovary.Austral – Asian Journal of Cancer, Vol 3, No. 2. April 2004, pp. 121-130.
    4. Bindhu Joseph , Anupama G Radiosensitization : The New Dogma in cancer treatment Austral – Asian Journal of Cancer, Vol.4. No.4. October 2005,pp.241-5-250
    5. Bindhu Joseph, Attili V.S. Suresh Epidermal Growth Factor Targeted Therapy; Are We Ready for These Magic Bullets? Austral - Asian Journal of Cancer ISSN-0972-2556, Vol. 6, No.2, April 2007
    6. Attili Suresh, P Bapsy,. H. Nademul, K Sabita, Bindhu Joseph Govind Babu K, Dasappa Lokanatha, Ullas Batra, J Ankit, KV Sajeevan, Anupama, G., Shiv Kamal.P10 Scoring system to predict mucositis in patients receiving chemoradiation for oral cancers – preliminary study from India. Oral Oncology Supplement.
    7. Bindhu Joseph, Dr. Lokanath, Sanjay Supe, B.Krishnamurthy Reddy, Primary Thymic Carcinoma: is there a role for Neoadjuvant Chemotherapy : A case report Austral- Asian Journal of Cancer, Vol 7, No. 1, Jan 2008 Pg 5-9
    8. Lokesh Vishwanath, Bindhu Joseph, K.B.Reddy, B.L.Preethi, Paper 2729. Granulocyte –Colony Stimulating Factor (G-CSF) Accelerates healing of Radiation induced Moist Desquamation- Int J Radiat Oncol Biol Phys (Supplement-2008 )
    9. Bindhu Joseph, Supe Sanjay, Yeshwanth Pawar- Intensity modulated radiotherapy (IMRT) the white black and grey: a clinical perspective Rep Pract Oncology Radiotherapy 2009, 14/03/:95-103
    10. Bindhu Joseph, Inthyaz.A rare presentation of cystic variant of favorable histology Wilms tumor presenting with osteolytic metastases to ribs. Journal of post graduate medicine (2010)
    11. Lokesh Viswanath, Reddy, K. Vidyasagar, M. Koteshwar, R. Ashok Shenoy, Naveen Thimmaiah, Govind Babu K, Bindhu Joseph, Bapsy, P.. (2009). A Phase IIb, 4 Arm Open-label, Randomized Trial, to Assess the Safety and Efficacy of Concurrent hR3 Monoclonal Antibody against EGF-receptor with Chemoradiation Therapy or with Radiation Therapy in Patients with Advanced (Stage III–IVa), Inoperable Head and Neck Cancer.75. 10.1016/j.ijrobp.2009.07.059
    12. Bindhu Joseph, Sanjay Supe, Ramachandra, Aruna. (2010). Cyberknife: A double edged sword?. Reports of Practical Oncology & Radiotherapy. 15. 93-97. 10.1016/j.rpor.2010.05.002.
    13. Govind Babu, K Lokesh Viswanath, Krishnamoorthy Bayyareddygari , Shenoy, K. Ashok Shenoy, Naveen Thimmaiah, Bindhu Joseph, Vidyasagar, M. Bonanthaya,R. Tanvir Pasha, Bapsy, P Aravind, A Eswaraiah, Anand Gupta, N. (2010). An open-label, randomized, study of h-R3mAb (nimotuzumab) in patients with advanced (stage III or IVa) squamous cell carcinoma of head and neck (SCCHN): Four-year survival results from a phase IIb study.. Journal of Clinical Oncology. 28. 5530-5530. 10.1200/jco.2010.28.15_suppl.5530.
    14. Lokesh Viswanath, Bindhu Joseph, Krishnamurthy, B Suresh, K. (2012). Granulocyte-Colony Stimulating Factor (G-CSF) accelerates healing of radiation induced moist desquamation of the skin. Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti. 25. 199-205.
    15. Bindhu Joseph, Lokesh Viswanath, Bindu Venugopal. (2014). Radiosensitization in head and neck cancer: Do we have an alternative to platins? Role of taxanes. Oral surgery, oral medicine, oral pathology and oral radiology. 117. 10.1016/j.oooo.2013.10.006.
    16. Krishnamoorthy Bayyareddygari, Lokesh Viswanath, Vidyasagar, M.S, K Shenoy, Govind Babu K , Ashok Shenoy, Naveen Thimmaiah, Bindhu Joseph, Bonanthaya, R. Nanjundappa, Bapsy, P.P. Loknatha, Jayarama Shetty, Krishna Prasad, Tanvir Pasha. (2014). Nimotuzumab provides survival benefit to patients with inoperable advanced squamous cell carcinoma of the head and neck: A randomized, open-label, phase IIb, 5-year study in Indian patients. Oral Oncology. 50. 10.1016/j.oraloncology.2013.11.008.
    17. Lokesh Viswanath, Naveen Thimmaiah, Siddanna Palled, P Chetana,. M Geethasree, P Sridhar, Tanvir Pasha, Bindhu Joseph, Kallur Pramod, D Ashalatha, V Priyadarshni, G Ajai, V Ashwini, A Mahalakshmi, T Riach, S Sugashwaran, T Yeshaswini, (2014).Epidermal growth factor receptor (EGFR) overexpression in patients with advanced cervical cancer. Journal of Clinical Oncology.
    18. Bindhu Joseph, Nisma Farooq, Muhammed Shafeeque, Sathiyan, S. & Lokesh Viswanath, C Ramesh, Vijay, C.. (2017). Hypofractionation in postmastectomy breast irradiation. How safe are we in using standard tangentials?Asian Journal of Oncology. 03. 101-105. 10.4103/ASJO.ASJO_53_17.
    19. Bindhu Joseph, K Sruthi , Lokesh Vishwanath.EGFR Targeting in Oesophageal Squamous Cell Carcinoma: Potential Role and Rationale. Clin Oncol. (2017; 2: 1247).
    20. Bindhu Joseph , Farooq N, Kumar S, Vijay CR, Puthur KJ, Ramesh C, Lokesh V.(2018) Breast-conserving radiotherapy with simultaneous integrated boost; field-in-field three-dimensional conformal radiotherapy versus inverse intensity-modulated radiotherapy–A dosimetric comparison: Do we need intensity-modulated radiotherapy?. South Asian journal of cancer. 2018 Jul;7(3):163.
    21. A Thimmarayappa,L Vishwanath,N Thimmaiah,L Bindhu Joseph, K Jagannath,T Pasha,V Ramaiah.Dosimetric comparison of prone vs supine partial breast irradiation via EBRT in early breast cancer.(2018)
    22. Bindhu Joseph . Dysphagia Associated Organ Sparing Radiotherapy: Defining the Limits of Tolerance for Late Toxicity. Advances in Modern Oncology Research. (2019 Apr 18;4(5):11).
    23. Bindhu Joseph , Vishal Malavade , Nisarga VM, Vijay CR, Ramesh C, Lokesh Vishwanath . Target delineation in high-grade glioma do CTV margins make a difference? ESTRO ACROP versus RTOG guidelines a comparative dosimetric study. Advances in Modern Oncology Research. (2019 Oct 18;4(6).
    24. Bindhu Joseph, Nikhila Radhakrishna,Nithin Bhaskar V, Lokesh Vishwanath.Cervical Cancer in the COVID-19 Era – the Potential Role of Adapting Newer Treatment Protocols . Advances in Modern Oncology Research .(2020)
    25. Dr Bindhu Joseph , Dr Nithin Bhaskar V, Dr Nikhila K R , Dr Sanjay R4 , Dr Lokesh V. Hypofraction... Revisited: The emerging role of shorter treatment schedules for locally advanced cancers during the COVID-19 pandemic. JMSCR Vol|09|Issue|02|February (2021)
    26. Bindhu Joseph, Muralikrishna Ramachandra, Nithin Bhaskar Valuvil,Lokesh Vishwanath. Simultaneous Modulated Accelerated Radiotherapy (SMART) with Dysphagia Aspiration-Related Structures (DARS) Sparing: Do We Have a Role for Dose Condensation in Locally Advanced Head and Neck Cancer.(2022) .Asian journal of oncology. (2022)


    National Journals:

    1. Bindhu Joseph, K.M.Ganesh, Sanjay S Supe Mathematical Modeling: Rationale of Clinical Application. Journal of Clinical Radiotherapy & Oncology, vol 4, No. 2: 10-14, June 2004.
    2. Bindhu Joseph, B.KrishnaMurthy Reddy, Nimit Singhal, T.Naveen, V. Lokesh, G.V.Giri.Extensive subcutaneous metastasis from squamous cell carcinoma of the oesophagus: A case report.Journal of Clinical Radiotherapy and Oncology, Vol 4, No. 3: pp 50-52, September, 2004.
    3. Ramachandra C, Suraj Manjuntha ,Bindhu Joseph, LL. Appaji, C.R.Rao, , Small bowel metastases from esophageal and oropharyngeal cancers.Indian Journal of Gastroenterology.(2005)
    4. Bindhu Joseph Ramachandra C, Suraj Manjuntha, C.R.Rao, LL. Appaji, B.S.Aruna Kumari, P.S.Prabhakaran.Mixed Exocrine-Endocrine Tumor of the Pancreas in Childhood. Indian Journal of Gastro-Enterology (2005)
    5. Bindhu Joseph,Imtiaz Ahmed,Rekha Kumar,Thejaswini, M Cystic variant of favorable-histology Wilms tumor presenting with osteolytic metastasis to the ribs. Journal of postgraduate medicine.(2010)
    6. Bindhu Joseph, Jayshree, R.S..Empirical antibiotic treatment in patients with carcinoma cervix being treated with radiotherapy: Are we ignoring antimicrobial resistance?. Austral-Asian J Cancer.
    7. Bindhu joseph.CT for staging in Head and Neck and Oaral cancer.How accurate are we?Are we underestimating our clinical target volume?(2018)
    8. Bindhu Joseph , Farooq N, Kumar S, Vijay CR, Puthur KJ, Ramesh C, Lokesh V.K Nithin.Breast-conserving radiotherapy with simultaneous integrated boost; A dosimetric comparison of 3DCRT,VMAT and IMRT. Do we really have a better plan?Indian Journal of Gynecologic and Oncology.(2019)
    9. Bindhu Joseph, Kurian J Puthur, Rekha V Kumar, Champaka G, Lokesh v, Ashok Shenoy, Sabitha K S, Ramesh C.Computed tomography for staging in head and neck and oral cancer.How accurate are we? Are we underestimating our clinical target volume?Journal of Medical Science and Clinical Research.Vol 6 Issue 11 november 2018.
    10. Bindhu Joseph, Vedamanasa Ikkurti, Nisma Farooq .Breast conserving radiotherapy with simultaneous integrated boost- A dosimetric comparison of 3DCRT,VMAT,and IMRT:Do we really have a better plan? Indian Journal of Gynecologic Oncology.June 2019.
    11. Lokesh Viswanath, Naveen Thimmaiah, Siddanna Palled, P Chetana,. M Geethasree, P Sridhar, Tanvir Pasha, Bindhu Joseph, Kallur Pramod, D Ashalatha, V Priyadarshni, G Ajai, V Ashwini, A Mahalakshmi, T Riach, S Sugashwaran, T Yeshaswini, (2014).Epidermal growth factor receptor (EGFR) overexpression in patients with advanced cervical cancer. Journal of Clinical Oncology.
    12. Krishnamoorthy Bayyareddygari, Bindhu Joseph, Bindu Venugopal - Recent advances in radiotherapy for the management of cancer. Apollo Medicine.
    13. Attili Suresh, P Bapsy,. H. Nademul, K Sabita, Bindhu Joseph Govind Babu K, Dasappa Lokanatha, Ullas Batra, J Ankit, KV Sajeevan, Anupama, G., Shiv Kamal.P10 Scoring system to predict mucositis in patients receiving chemoradiation for oral cancers – preliminary study from India. Oral Oncology Supplement.
    14. C Ramachandra, Suraj Manjunath, Bindhu Joseph, L Appaji, L, Banita Kumari, Clementina Rama Rao, P Prabhakaran.Mixed exocrine-endocrine pancreatic carcinoma in childhood. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.(2005)
    15. Bindhu Joseph, Rekha V Kumar, Champaka G, Ashok Shenoy, Sabitha KS, Lokesh Viswanath,Ramesh C,C Vijay.Biological tailoring of adjuvant radiotherapy in head and neck and oral malignancies – The potential role of p53 and eIF4E as predictive parameters. Indian Journal of Pathology and Oncology. (2019)
    16. Bindhu Joseph, C Ramachandra,S Manjunath ,L Appaji,Kumari Bs,Rao Cr,P.Prabhakaran. Small bowel metastases from esophageal and oropharngeal cancers.Indian journal of Gastroenterology.(May 2005)